NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation (Adv. Sci. 30/2026)

EV-Mediated mRNA Trafficking The cover image illustrates how extracellular vesicles (EVs) mediate the transfer of genetic information between cells in the tumor microenvironment. Ying Zhang, Hang Yin, Kaixiang Zhang, and co-workers uncover that the RNA-binding protein NPM1 selectively loads mRNAs into EVs, which are then delivered to recipient cells to reprogram cellular behavior and support tumor-associated processes. In the illustration, the soccer ball symbolizes EVs carrying NPM1-mRNA complexes, while the players represent cells engaged in dynamic intercellular communication through EV-mediated cargo transfer. More details can be found in the Research Article (DOI: 10.1002/advs.202514852). The cover art was created by Xiaonan Wang.