Oral Motion‐Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect

ABSTRACT The long‐term clinical success of dental implants is critically dependent on achieving stable soft‐tissue integration while preventing bacterial colonization and subsequent peri‐implantitis. Piezoelectric biomaterials offer a route to address this challenge, yet the potential to harness ambient oral motions (e.g., mastication) as a continuous power source for autonomous therapeutic action remains largely unexplored. Here, we report a motion‐activated smart dental implant abutment (SDIA) constructed from a toughened piezoelectric composite comprising a 3D interconnected barium titanate (BaTiO ₃ ) ceramic framework infiltrated with a high‐strength polymer matrix. This architecture imparts exceptional flexural strength and fracture toughness via polymer‐mediated crack deflection. Under simulated oral pressure, the SDIA demonstrates efficient biomechanical‐to‐electrical energy conversion, driving a potent piezo‐catalytic effect that generates sufficient reactive oxygen species (ROS) to eradicate 96.5% of E. coli and 89.7% of S. aureus , and robustly inhibits biofilm formation. Concurrently, the motion‐induced electrical cues directly modulate fibroblast behavior by upregulating the MAPK and PI3K‐Akt signaling pathways, substantially enhancing cell adhesion and proliferation. This work establishes a new paradigm for smart biomaterials, demonstrating that harnessing natural physiological motion can power autonomous implants capable of delivering synergistic antibacterial and regenerative therapies to prevent clinical device failure.