Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Source abstract
Abstract
ABSTRACT Cellular senescence drives inflammation and tissue breakdown and is a key hallmark of aging. The accumulation of senescent cells is strongly linked to the degeneration of spinal tissues and back pain. Here, we show that administration of the senolytic agents, o‐vanillin and RG‐7112, prevents the development of pain‐related behavior in sparc −/− mice. Treated mice exhibit a reduced expression of senescence markers in the intervertebral discs, vertebral endplates, vertebral bone, and spinal cord, alongside a dampening of pro‐inflammatory senescence‐associated secretory factors in these tissues. Early senolytic intervention also preserved intervertebral disc volume and vertebral bone microarchitecture, indicating protection against structural spine degeneration. These findings demonstrate that targeting cellular senescence at an early stage can mitigate degenerative changes and pain, supporting senolytic therapy as a promising preventive strategy for musculoskeletal decline.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Spine and Intervertebral Disc Pathology · Retinoids in leukemia and cellular processes · Spinal Cord Injury Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Surgery Orthopaedic Research Lab McGill University Montreal Quebec Canada
Department of Surgery McGill Scoliosis and Spine Group McGill University Montreal Quebec Canada
Alan Edwards Centre For Research on Pain (AECRP) McGill University Montreal Quebec Canada
ABC‐platform (Animal Behavioral Characterization) At the Alan Edwards Centre for Research on Pain McGill University Montreal Quebec Canada
Département de biomédecine vétérinaire Faculté de médecine vétérinaire Université De Montréal Saint‐Hyacinthe Quebec Canada
Shriner's Hospital for Children Montreal Quebec Canada
Department of Anesthesiology University of Minnesota Minneapolis Minnesota USA
Funding
Arthritis Society · Réseau de Recherche en Santé Buccodentaire et Osseuse · Canadian Institutes of Health Research · Fonds de recherche du Québec
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