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journal article·2026-05-25Open access

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng

Advanced Science
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Abstract

ABSTRACT Adipokines are key factors in regulating energy homeostasis. We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. Leptolin levels were positively correlated with lipolysis‐promoting gene expression. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals. Leptolin gene‐knockout mice exhibited increased adiposity and body weight, and decreased energy expenditure. Transgenic leptolin overexpressing in mice showed obesity‐resistant phenotypes. Treatment with leptolin promoted fat mobilization, increased energy expenditure, and reduced body weight, without affecting food‐intake or motor activity. Leptolin is a novel adipokine with a capacity to improve metabolic status and may serve as a new therapeutic agent for obesity and metabolic disorders.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Adipokines, Inflammation, and Metabolic Diseases · Adipose Tissue and Metabolism · Exercise and Physiological Responses

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Anatomy Histology and Embryology School of Basic Medical Sciences Peking University Beijing China

Department of Pharmaceutical Analysis and State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing China

Biomedical Engineering Department Peking University Beijing China

China Institute of Sport and Health Science Beijing Sport University Beijing China

Sport Science College Beijing Sport University Beijing China

State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular Pharmacology Peking University Beijing China

Department of Medical Genetics Center for Medical Genetics Peking University Health Science Center Beijing China

Neuroscience Research Institute Peking University Beijing China

Key Laboratory for Neuroscience Ministry of Education/National Health Commission Peking University Beijing China

Beijing Life Science Academy Beijing China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Natural Science Foundation of Beijing Municipality

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