PVN ^CRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons (Adv. Sci. 29/2026)

Chronic Migraine Chronic NTG injection pathologically activates PVNCRF neurons, leading to excessive release of CRF neuropeptides into the downstream nucleus SP5C. The elevated CRF neuropeptides aberrantly activate CRFR2 receptors on SP5CGlu neurons, resulting in hyperexcitability of these neurons and ultimately triggering migraine-like Allodynia. More details can be found in the Research Article by Xu Jing, Mei-Yun Wang, Xu-Feng Xu, and co-workers (DOI: 10.1002/advs.202520530).