Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men (Adv. Sci. 28/2026)

Human Muscle Regeneration This frontispiece shows regenerating human skeletal muscle stained for embryonic myosin heavy chain (eMyHC) eight days after high intensity contraction and daily Nicotinamide and Pyridoxine supplementation. eMyHC-positive fibers mark newly formed myofibers arising from activated muscle stem cells. Nicotinamide and pyridoxine supplementation enhances this regenerative process by promoting muscle stem cell proliferation, differentiation, and progression toward muscle repair. More details can be found in the Research Article by Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey, and co-workers (DOI: 10.1002/advs.202518471).