Single‐Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label‐Free Metabolic Microscopy (Adv. Sci. 28/2026)

Fat Tissue Remodeling by Label-Free Metabolic Microscopy Label-free mid-infrared optoacoustic microscopy (MiROM) visualizes single-cell lipid and protein vibrational contrast in intact adipose tissue, preserving native architecture. Combined with an AI-based quantitative spatial analysis tool (Q-SAT), MiROM digitally scores white- and brown-like adipocyte features, enabling rapid phenotyping of adipose tissue remodeling. More details can be found in the Research Article by Yongguo Li, Miguel A. Pleitez, and co-workers (DOI: 10.1002/advs.202513042).