Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair (Adv. Sci. 28/2026)

Tracheal Repair A cascade-responsive MXene@Cu-MOF/GelMA hydrogel is engineered as a “skeleton-backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu-MOF component provides pH/NIR-responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis. In orthotopic rabbit models, this integrated strategy supports vascularized cartilage regeneration and long-segment airway reconstruction with systemic safety. More details can be found in the Research Article by Bo Tao and co-workers (DOI: 10.1002/advs.202521174).