Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum (Adv. Sci. 27/2026)

Non-Invasive Cholangiocarcinoma Detection The frontispiece, inspired by traditional Chinese ink wash painting, features a sweeping river evoking the Yellow River flowing from northwest to southeast, symbolizing the cross-regional generalizability of fecal metagenomic signatures for non-invasive cholangiocarcinoma (CCA) detection across diverse regions of China. Bifidobacterium pseudocatenulatum suppresses CCA progression, highlighting its role as a candidate protective microbe. More details can be found in the Research Article by Zhigang Ren and co-workers (DOI: 10.1002/advs.202517658).