Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis (Adv. Sci. 27/2026)

Osteoarthritis Interface-derived nanocrystal fragmentation and ectopic deposition induced by mechanical overloading initiates osteoarthritis (OA). Nano crystals deposition in deep cartilage extra cellularmatrix (ECM) changed mechanical microenvironment of hypertrophic chondrocytes in front of osteochondral interface. Upregulated fibronectin and vitronectin promoted calcified MVs secretion, which induced bottom-up ECM mineralization and OA progression. More details can be found in the Research Article by Zhen Li, Chao Li, Songsong Zhu, and co-workers (DOI: 10.1002/advs.202516893).