DataVXAdvanced SciencePaper
journal article·2026-07Open access

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang

Advanced Science· Volume 13· Issue 39
Publisher pageOpen full text
Source abstract

Abstract

ABSTRACT Probiotic therapy that targets fat absorption in the small intestine holds considerable potential for regulating lipid metabolism, yet it faces challenges related to spatiotemporal delivery and colonization efficiency. To address these issues, an enzyme‐probiotic biohybrid (AKK‐COD) has been developed and subsequently encapsulated in thiol‐modified alginate hydrogel microspheres. This therapeutic system enables sequential functions: intragastric protection, small intestinal adhesion, and probiotic release and colonization. The Ca 2+ ‐crosslinked hydrogel maintains structural integrity under acidic gastric conditions, ensuring protection of probiotics and enzymes while facilitating timely gastric emptying. Upon reaching the small intestine, the microspheres adhere to the small intestinal mucosa via disulfide linkage, enhancing local retention. Concurrently, the gradual dissociation of ionic crosslinks within the hydrogel allows the release of AKK‐COD, which participates in the catalytic conversion of cholesterol, modulates lipid absorption pathways, and promotes microbial homeostasis. In vivo experiments demonstrate that this approach significantly alleviates high‐fat diet‐induced hypercholesterolemia, offering a safe and efficient strategy for lipid‐lowering therapies.
Source: crossref · Quality: baseline

Research context

PolymersCatalysis & surfaces

OpenAlex topics: Hydrogels: synthesis, properties, applications · Supramolecular Self-Assembly in Materials · Enzyme Catalysis and Immobilization

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of General Surgery The Fifth Affiliated Hospital Sun Yat‐sen University Zhuhai P. R. China

Department of General Surgery (Thyroid Surgery) Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research Center Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou P. R. China

Department of Colorectal Surgery Foresea Life Insurance Guangzhou General Hospital Guangzhou P. R. China

Colorectal Surgery Unit III Guangdong Institute of Gastroenterology Biomedical Innovation Center Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat‐sen University Guangzhou P. R. China

Key Laboratory of Human Microbiome and Chronic Diseases, Ministry of Education Sun Yat‐sen University Guangzhou P. R. China

PCFM Lab School of Chemistry Sun Yat‐sen University Guangzhou P. R. China

The Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen P. R. China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Science and Technology Planning Project of Guangdong Province

References (29)

Show source-provided references
1. 10.1016/j.tcb.2024.12.00210.1016/j.tcb.2024.12.002 ↗
2. 10.1016/j.tcb.2024.12.00210.1016/j.tcb.2024.12.002 ↗
3. 10.1016/j.cmet.2021.09.00110.1016/j.cmet.2021.09.001 ↗
4. 10.1016/j.cmet.2023.02.00310.1016/j.cmet.2023.02.003 ↗
5. 10.1016/j.addr.2020.06.02710.1016/j.addr.2020.06.027 ↗
6. 10.1136/gutjnl‐2024‐33307410.1136/gutjnl‐2024‐333074 ↗
7. 10.1038/s41580‐019‐0190‐710.1038/s41580‐019‐0190‐7 ↗
8. 10.1093/eurheartj/ehab72310.1093/eurheartj/ehab723 ↗
9. 10.1126/science.adf096610.1126/science.adf0966 ↗
10. 10.1038/s41591‐019‐0495‐210.1038/s41591‐019‐0495‐2 ↗
11. 10.1038/s41564‐021‐00880‐510.1038/s41564‐021‐00880‐5 ↗
12. 10.1016/j.tim.2022.08.00310.1016/j.tim.2022.08.003 ↗
13. 10.1038/s41575‐022‐00631‐910.1038/s41575‐022‐00631‐9 ↗
14. 10.1038/s41579‐024‐01106‐110.1038/s41579‐024‐01106‐1 ↗
15. 10.1002/adma.20231017410.1002/adma.202310174 ↗
16. 10.1016/j.chom.2020.05.01310.1016/j.chom.2020.05.013 ↗
17. 10.1016/j.cell.2024.03.01410.1016/j.cell.2024.03.014 ↗
18. 10.1002/adma.20221094910.1002/adma.202210949 ↗
19. 10.1038/s41551‐024‐01224‐410.1038/s41551‐024‐01224‐4 ↗
20. 10.3390/pharmaceutics1406125810.3390/pharmaceutics14061258 ↗
21. 10.1093/gastro/goaf01010.1093/gastro/goaf010 ↗
22. 10.1007/s11883‐023‐01147‐610.1007/s11883‐023‐01147‐6 ↗
23. 10.1093/eurheartj/ehab64410.1093/eurheartj/ehab644 ↗
24. 10.1186/s12944‐019‐1103‐710.1186/s12944‐019‐1103‐7 ↗
25. 10.1093/gastro/goac00810.1093/gastro/goac008 ↗
26. 10.3390/nu1511261010.3390/nu15112610 ↗
27. 10.1016/j.chom.2022.07.01510.1016/j.chom.2022.07.015 ↗
28. 10.1186/s12916‐022‐02376‐310.1186/s12916‐022‐02376‐3 ↗
29. 10.3390/ijms24151223210.3390/ijms241512232 ↗