Versatile DNA‐Functionalized Biohybrid Hydrogel Platforms for Electrothermally Activated On‐Demand Payload Release
Source abstract
Abstract
ABSTRACT Current drug delivery systems struggle to achieve precise control, rapid response, and high biocompatibility. Addressing these challenges, we developed an electrothermally responsive biohybrid hydrogel incorporating DNA‐functionalized nanostructures for on‐demand payload release. Unlike conventional platforms relying on passive diffusion or biochemical triggers, our system utilizes electrical stimulation to produce localized heating that simultaneously alters DNA conformation and hydrogel structure. This dual mechanism enables rapid electrically controlled release within seconds while preserving excellent biocompatibility. The modular DNA design permits easy customization through sequence modifications, enabling flexible adaptation for diverse therapeutic applications, including precision oncology, neural regulation, and chronic wound healing.
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Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced biosensing and bioanalysis techniques · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems Great Bay University Dongguan Guangdong China
Department of Materials Science and Engineering Southern University of Science and Technology Shenzhen Guangdong China
Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics Guangdong Medical University Dongguan China
Funding
National Natural Science Foundation of China · Basic and Applied Basic Research Foundation of Guangdong Province
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