Quantum Nanomedicine and Quantum Biomaterials

ABSTRACT Quantum nanomedicine and quantum biomaterials, as an interdisciplinary field, deeply integrate quantum science, material science, nanotechnology, biology, and medicine. Here, we define quantum nanomedicine and quantum biomaterials as a paradigm that harnesses quantum effects in nanomedicine and biomaterials, including quantum superposition, quantum coherence, quantum tunneling, topological quantum effects, and spin polarization, to achieve either spatiotemporally precise modulation of physiological activity and therapeutic intervention or the enhancement of intrinsic physiochemical properties for amplified therapeutic outcomes. This article systematically elucidates how quantum effects govern fundamental life processes and prospectively explores their potential in enabling innovative therapeutic strategies. The typical mechanisms of quantum biological effects involve quantum coherence in photosynthetic energy transfer, spin polarization in modulating reactive oxygen species generation, and quantum biological electron tunneling as verified in cytochrome c (Cyt c). These principles provide a theoretical foundation for the rational design of quantum nanomedicine and biomaterials. By controlling quantum coherence, quantum tunneling, and spin properties, the precise spatiotemporal regulation of biomolecular interactions and cellular signaling pathways can be achieved. The herein proposed quantum nanomedicine and quantum biomaterials establish a new paradigm for intervening in life processes at electronic and informational levels, thereby laying a scientific foundation for developing next‑generation diagnostic and therapeutic platforms.