journal article·2026-07Open access

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song

Advanced Science· Volume 13· Issue 40

Abstract

ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation requirements. Here, we report the development of a self‐healing colloidal gelatin hydrogel engineered as a flowable hemostatic matrix and successfully demonstrate its bench‐to‐bedside translation into a biomedical device (Colloidose). Specifically, amphoteric gelatin sub‐microparticles self‐assemble into an integrated gel network exhibiting a high storage modulus (G’ > 15 kPa) and a healing efficiency exceeding 95%, enabling rapid in situ solidification to accelerate blood clot formation. By benchmarking against conventional flowable matrices composed of coarse hundreds of micrometer‐sized gelatin granules, we demonstrate that Colloidose offers superior hemostatic efficacy in anatomically challenging or pressure‐intolerant sites (e.g., hepatobiliary, otorhinolaryngological, and gynecologic surgeries). Supported by comprehensive preclinical studies and over 300 clinical cases, Colloidose exemplifies the successful translation of an advanced self‐healing biomaterial, establishing its role as a next‐generation hemostat and opening new avenues for injectable and moldable biomedical devices.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: 3D Printing in Biomedical Research · Hydrogels: synthesis, properties, applications · Hemostasis and retained surgical items

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopedic Surgery and Orthopedic Research Institute & West China Hospital Sichuan University Chengdu China

MOE Key Laboratory of Bio‐Intelligent Manufacturing Dalian Key Laboratory of Artificial Organ and Regenerative Medicine School of Bioengineering Dalian University of Technology Dalian China

State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology Dalian China

Shenzhen Huanova Biotechnology Co., Ltd Shenzhen China

Affiliated Central Hospital of Dalian University of Technology Dalian China

Department of Colorectal Surgery Second Affiliated Hospital of Navy Medical University Shanghai China

Department of Otolaryngology The Third People's Hospital of Dalian Affiliated to Dalian University of Technology Dalian China

Department of Ophthalmology The Third People's Hospital of Dalian Affiliated to Dalian University of Technology Dalian China

Department of Orthopaedics State Key Laboratory of Common Mechanism Research for Major Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Department of Neurosurgery Shenzhen Hospital of Peking University Shenzhen China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Natural Science Foundation of Liaoning Province · Dalian University of Technology

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