FomA‐Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL‐6‐Dependent M2b Macrophage Polarization (Adv. Sci. 23/2026)

Bladder Cancer Lymphatic Metastasis On this cover, the Flaming Mountains episode from Journey to the West is reimagined to portray bladder cancer lymphatic metastasis. The Monkey King symbolizes FomA-containing outer membrane vesicles from Fusobacterium nucleatum, while the false plantain fan represents IL-6-driven M2b-polarized macrophages that intensify rather than extinguish the flames of tumor spread. This scene reflects the findings of Liang et al., who uncover the FomA-TLR2-NF-κB axis and identify pinocembrin as a therapeutic blocker of this prometastatic pathway. More details can be found in the Research Article by Zongwei Wang, Jie Zhao, Peng Wu, Bisheng Cheng, and co-workers (DOI: 10.1002/advs.202523256). The cover art was created by Coloring Dayu.