DataVXAdvanced SciencePaper
journal article·2026-06Open access

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou

Advanced Science· Volume 13· Issue 34
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Source abstract

Abstract

ABSTRACT Proprioception, often described as a sixth sense to perceive body position and muscle contraction, has been increasingly implicated in the development and maintenance of chronic pain, yet the underlying mechanisms remain unclear. Here, we identify the functional expression of TRPA1 in proprioceptive mesencephalic trigeminal nucleus (MeV) neurons in a mouse model of orofacial muscle pain. TRPA1 sensitization enhances somatic secretion from MeV neurons, thereby promoting the progression and persistence of inflammatory pain by disinhibiting descending pain control from the neighboring noradrenergic locus coeruleus (LC NE ) neurons. Local GABAergic neurons that provide input to LC NE neurons serve as a key downstream target of MeV somatic volume transmission, forming a critical relay that transduces signals from the MeV to the LC NE system. Thus, these findings reveal a previously unrecognized somatic volume transmission that links proprioceptive and nociceptive circuits and provides a central mechanism for persistent muscle pain.
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Research context

OpenAlex topics: Pain Mechanisms and Treatments · Ion Channels and Receptors · Gastrointestinal motility and disorders

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Central Laboratory Peking University School and Hospital of Stomatology Institute of Molecular Medicine and Peking‐Tsinghua Center for Life Sciences State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine PKU‐IDG/McGovern Institute for Brain Research Peking University Beijing China

Department of Neural and Pain Sciences School of Dentistry; Program in Neuroscience Center to Advance Chronic Pain Research University of Maryland Baltimore Maryland USA

Peking University Hospital of Stomatology Sanya Division (Sanya Stomatology Center) Sanya China

Department of Cardiology Zhongshan Hospital Institutes of Biomedical Sciences Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai China

Neuroscience Research Center National Key Laboratory for High Energy Pulsed Power Key Laboratory of Biomedical Information Engineering of the Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an China

Key Laboratory of Medical Electrophysiology Ministry of Education of China Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, and the Institute of Cardiovascular Research Southwest Medical University Luzhou China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Fundamental Research Funds for the Central Universities

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