Dual‐Mode Type I/II Photosensitization of a Stable Mesoporous Hydrogen‐Bonded Organic Framework for Antibacterial Therapy

ABSTRACT In contrast to monomers that are randomly distributed in solution or in an amorphous state, constructing a highly crystalline framework with precise molecular arrangement might provide materials with markedly enhanced functionalities. Herein, a large π ‐conjugated electron donor–acceptor (D–A) type molecule was designed and synthesized, which self‐assembles through hydrogen bonds to form an organic framework named PFC‐513. The ordered arrangement dramatically boosts the quantum yield (ΦΔ) of singlet oxygen generation, classified as type IIreactive oxygen species (ROS), from 0.01 for the monomer to 0.98 for PFC‐513, while enabling the hydroxyl radical generation (type I ROS), which is absent in the monomeric state. Such dual‐mode Type I/II Photosensitization grants PFC‐513 potent antibacterial activity against methicillin‐resistant bacteria and E. coli . Beyond direct antibacterial action, PFC‐513 can simultaneously downregulate key pro‐inflammatory cytokines and chemokines under light irradiation for a diabetic wound, therefore synergistically accelerating wound healing. This work establishes a new paradigm for engineering crystalline porous frameworks with superior PDT efficacy, offering a promising strategy for combating infections and promoting wound repair.