Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3 (Adv. Sci. 20/2026)

Lactylation-Driven YTHDC1 Alleviates MASLD The reduction of YTHDC1 triggers a vicious cycle: its degradation leads to the release of free LDHA, which further accelerates YTHDC1 loss. This cycle exacerbates hepatic inflammation and lipid accumulation by activating the PTPN22/NLRP3 axis. This study reveals a novel strategy of targeting this pathway to tame the metabolic torrent and disrupt MASLD progression. More details can be found in the Research Article by Tianqi Duo, Linqiang Li, Yu Bian, and co-workers (DOI: 10.1002/advs.202510192).