journal article·2026-05Open access

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang

Advanced Science· Volume 13· Issue 25

Abstract

ABSTRACT Exosomes serve as intercellular communication vectors and are involved in a broad range of physiological functions. Although exosome‐based therapies have demonstrated diverse functional potential, the regulatory mechanisms underlying their biogenesis and secretion remain poorly understood. Here, we report that TEAD1 functions as a molecular switch, dramatically enhancing the synthesis and secretion of exosomes. Mechanistically, TEAD1 enhances exosome secretion by promoting the expression of exosome secretion‐associated proteins RAB11, CD9, and SNAP23. We found that TEAD1 enhances exosome secretion from adipose‐derived mesenchymal stem cells, thereby promoting skin wound healing in diabetic mice. Similarly, TEAD1 promotes the release of exosomes from bone marrow‐derived mesenchymal stem cells, thereby facilitating spinal cord injury (SCI) repair. Our study elucidates a novel role for TEAD1 in driving exosome secretion in different cell types, highlighting the therapeutic potential of TEAD1 in enhancing tissue regeneration, particularly in diabetic wound healing and SCI repair.
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Research context

OpenAlex topics: Hippo pathway signaling and YAP/TAZ · Extracellular vesicles in disease · Planarian Biology and Electrostimulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Clinical Research Center for Cell‐based Immunotherapy of Shanghai Pudong Hospital Fudan University Pudong Medical Center State Key Laboratory of Genetics and Development of Complex Phenotypes School of Life Sciences Human Phenome Institute Fudan University Shanghai China

Analysis Center Chemistry Department Tsinghua University Beijing China

Department of Spine Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China

Department of Cancer Research Institute Xinjiang Key Laboratory of Translational Biomedical Engineering Affiliated Cancer Hospital of Xinjiang Medical University Urumqi China

CAS Center for Excellence in Molecular Cell Science Cell Bank Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai China

Department of Pediatric Orthopedics Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Program of Shanghai Academic Research Leader · China Postdoctoral Science Foundation

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