DataVXAdvanced SciencePaper
journal article·2026-05Open access

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng

Advanced Science· Volume 13· Issue 26
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Source abstract

Abstract

ABSTRACT The significance of adipose tissue macrophages (ATMs) in regulating adipose tissue function is well‐established. However, our investigation revealed a previously overlooked subpopulation of macrophages adhered to adipocytes, which we term adhesion‐related macrophages (ARMs). We developed an approach to isolate ARMs and compared them with stromal vascular fraction (SVF) macrophages (SMs). Our findings demonstrate that ARMs constitute the predominant expanded subpopulation of ATMs during obesity, ARMs acquire adipocyte mRNA through direct adhesion to adipocytes, thereby enhancing their lipid processing capacity. Notably, ARMs can be characterized by a key functional marker, Caveolin‐1. Genetic ablation of Caveolin‐1 in macrophages significantly diminishes ARM abundance, disrupting their adhesion capacity and lipid content, leading to adipocyte hypertrophy, adipose tissue expansion, and impaired glucose homeostasis. Reintroducing ARMs from lean mice into epididymal white adipose tissue (eWAT) mitigates obesity‐induced insulin resistance. Our study uncovers ARM as a potential therapeutic target for obesity‐induced insulin resistance and opening avenues for identifying similar paradigms in other tissues and diseases.
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Research context

OpenAlex topics: Caveolin-1 and cellular processes · Adipokines, Inflammation, and Metabolic Diseases · Atherosclerosis and Cardiovascular Diseases

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National Clinical Research Center for Endocrine and Metabolic Diseases Key Laboratory of Diabetes Immunology, Ministry of Education and Department of Metabolism and Endocrinology and Metabolic Syndrome Research Center The Second Xiangya Hospital of Central South University Changsha Hunan China

Department of Endocrinology and Metabolism The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China

Endocrine and Metabolic Disease Center First Affiliated Hospital College of Clinical Medicine of Henan University of Science and Technology Luoyang Henan China

Department of Orthopedics The First Affiliated Hospital Hengyang Medical School University of South China Hengyang Hunan China

Department of Clinical Laboratory Sun Yat‐Sen Memorial Hospital of Sun Yat‐Sen University Guangzhou Guangdong China

NHC Key Laboratory of Birth Defect For Research and Prevention Hunan Provincial Maternal and Child Health Care Hospital Changsha Hunan China

Department of Kidney Transplantation Center of Organ Transplantation The Second Xiangya Hospital of Central South University Changsha Hunan China

Department of Biliopancreatic Surgery and Bariatric Surgery The Second Xiangya Hospital of Central South University Changsha Hunan China

Diabetes and Metabolism Research Center Division of Endocrinology Diabetes & Metabolism Department of Internal Medicine Wexner Medical Center of The Ohio State University Columbus Ohio USA

Department of Pharmacy The Second Xiangya Hospital of Central South University Changsha Hunan China

Hunan Provincial Engineering Research Centre of Translational Medicine and Innovative Drug Changsha China

FuRong Laboratory Changsha Hunan China

Funding

National Key Research and Development Program of China

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