journal article·2026-04Open access

A LDH‐Based Supramolecular Photosensitizer‐Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration

Tao Wang, Yixin Bian, Tingting Hu, Mengyang Li, Yuqin Tan, Yu Yang, Xiaolan Jian, Xisheng Weng, Chaoliang Tan, Ruizheng Liang

Advanced Science· Volume 13· Issue 22

Abstract

ABSTRACT Layered double hydroxide (LDH)‐based materials have been explored as efficient photosensitizers for photodynamic therapy (PDT) or functional agents for bone regeneration, holding great promise in the synergistic PDT‐mediated osteosarcoma treatment and bone reconstruction. Herein, we report the functionalization of 5‐iodoisophthalic acid (I‐IPA)‐intercalated MgZnAl‐LDH onto bioactive glass scaffold (BGS) to construct a bifunctional composite scaffold (BGS/I‐LDH) for integrated osteosarcoma treatment and bone regeneration. The surface functionalization of I‐LDH onto BGS confers BGS/I‐LDH high‐efficiency reactive oxygen species generation performance under 1270 nm laser irradiation, resulting in a singlet oxygen quantum yield up to 1.53, which is significantly superior to that of previously reported NIR‐excited PSs. Moreover, thanks to the sustained release of Mg 2+ and Zn 2+ ions from I‐LDH, BGS/I‐LDH exhibits exceptional anti‐osteosarcoma and osteogenic properties with 3.8‐fold bone volume, 3.0‐fold bone mineral density, and 11.4‐fold new bone mass increments compared with the pristine BGS, which is remarkably more preponderant than other previously reported modified BGS.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Layered Double Hydroxides Synthesis and Applications · Bone Tissue Engineering Materials · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing P. R. China

Department of Orthopedic Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing P. R. China

Department of Electrical Engineering & Department of Biomedical Engineering City University of Hong Kong Kowloon Tong Hong Kong SAR P. R. China

Graduate School Hunan University of Chinese Medicine Changsha Hunan P. R. China

Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine Changsha Hunan P. R. China

Hong Kong Branch of National Precious Metals Material Engineering Research Center (NPMM) City University of Hong Kong Kowloon Tong Hong Kong SAR P. R. China

Shenzhen Research Institute City University of Hong Kong Shenzhen P. R. China

Quzhou Institute For Innovation in Resource Chemical Engineering Quzhou P. R. China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China

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