Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome (Adv. Sci. 6/2026)

Genome Geometry as the Physical Language of Cell Memory This cover highlights the transformation of genome information from chemical states into dynamic physical geometry. Genetic and epigenetic states pass through a geometric prism, proposing that exons and non-exons couple as shell (gold) to volume (purple) ratios of ChromSTEM-resolved packing domains. The Research Article by Igal Szleifer, Vadim Backman, and co-workers (DOI: 10.1002/advs.202509964) advances a model in which cell memory resides not only in sequence composition, but in a heritably encoded 3D geometric language.