Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia (Adv. Sci. 5/2026)

Chaperone-to-Surface: Unveiling ER Stress Neoantigens for CAR Therapy The cover image depicts the translocation of endoplasmic reticulum (ER) chaperones to cell surface of cancer cells undergoing chronic ER stress, where they serve as potential neoantigens. Malignant cells can be attacked by engineered chimeric antigen receptor (CAR) immune cells through the targeting of these stress-induced neoantigens. This study proposes a novel strategy to eliminate malignant cells that survive chronic oncogenic stress, highlighting the promise of chaperone-targeted cellular immunotherapy as a proof-of-concept precision treatment. More details can be found in the Research Article by Qinmiao Sun, Tonghua Yang, Beibei Zhang, Dahua Chen, and co-workers (DOI: 10.1002/advs.202511573).