journal article·2026-01Open access

Temporal Stretch‐Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection (Adv. Sci. 5/2026)

Hye‐Won Shim, Ji‐Young Yoon, Hwalim Lee, Shanika Karunasagara, Cheng Ji Li, Yongdae Shin, Sukbum Hong, Dong‐Joon Lee, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim

Advanced Science· Volume 13· Issue 5

Abstract

Temporal Stretch-Induced Nuclear Mechanosensing Cells subjected to temporal mild stretching rapidly activate their nuclear mechanosensing machinery, leading to changes in nuclear mechanics and epigenetic states that upregulate genes involved in genome protection and cellular plasticity. More details can be found in the Research Article by Jung-Hwan Lee, Kam W. Leong, Hae-Won Kim, and co-workers (DOI: 10.1002/advs.202510554).
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Genomics and Chromatin Dynamics · Nuclear Structure and Function · RNA Research and Splicing

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