DataVXAdvanced SciencePaper
journal article·2026-01Open access

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin (Adv. Sci. 4/2026)

Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger

Advanced Science· Volume 13· Issue 4
Publisher pageOpen full text
Source abstract

Abstract

Unfractionated Heparin A billion pigs are utilized per year to meet the world's demand for heparin, a WHO essential medicine used for many cardiovascular indications. Creating sustainable anticoagulant drugs that can replace heparin is challenging. In their Research Article (DOI: 10.1002/advs.202509867), Haixiang Yu, Bruce A. Sullenger, and co-workers describe a novel approach that employs an EXACT inhibitor to target both the EXosite and ACTive site on thrombin.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Heparin-Induced Thrombocytopenia and Thrombosis · Proteoglycans and glycosaminoglycans research · Venous Thromboembolism Diagnosis and Management

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References

Reference metadata was not supplied for this record.