Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance
Source abstract
Abstract
ABSTRACT Plant pathogens pose a significant threat to global food security by causing up to 80% agricultural yield losses. Nucleotide‐binding, leucine‐rich repeat immune receptors (NLRs) were widely proved to protect plants from a wide array of pathogens evasion. Recent studies have shown significant progress in bioengineering NLRs to enhance plant immunity through improved pathogen recognition, investigation of immune evasion, and structural insights into NLR functions. However, bioengineering NLRs for enhanced plant immunity faces key challenges of maintaining specificity, addressing pathogen evolution, and minimizing autoactivity risks. Here, we synthesize recent advances in understanding NLR biology and highlight key bioengineering strategies, including mismatched pairs, domain swapping, and targeted mutagenesis, that leverage this knowledge to enhance disease resistance. The successful applications of NLRs precision editing strategies have also been demonstrated to improve resistance in various plants, showcasing their overall effectiveness. This review highlights promising avenues to strengthen plant immunity against pathogens, which have enormous potential for application in agriculture and breeding techniques.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: CRISPR and Genetic Engineering · Plant-Microbe Interactions and Immunity · Transgenic Plants and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural Bioengineering Center For Research and Development of Fine Chemicals, Ministry of Education Guizhou University Guiyang P. R. China
Department of Physiotherapy Vinoba Bhave University Hazaribagh Jharkhand India
Agriculture Biotechnology Centre Faculty of Agriculture University of Peradeniya Colombo Sri Lanka
School of Pharmaceutical Sciences Guizhou University Guiyang P. R. China
State Key Laboratory of Maize Bio‐Breeding Joint International Research Laboratory of Crop Molecular Breeding, Ministry of Agriculture Key Laboratory for Crop Pest Monitoring and Green Control China Agricultural University Beijing P. R. China
State Key Laboratory of Green Pesticide Central China Normal University Wuhan P. R. China
National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai P. R. China
Funding
National Key Research and Development Program of China · National Natural Science Foundation of China
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