DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex (Adv. Sci. 3/2026)

Lung Cancer Metastasis This cover illustrates the molecular cascade driving lung cancer metastasis. DCAF12 (top left), depicted as a master regulator, emits silver ubiquitin signals that direct the assembly of free TRiC/CCT subunits into a central protein-folding machine. Upon activation, this nanomachine paves the way for tumor invasion and distant spread by enhancing cytoskeletal integrity and ensuring the precise folding of oncogenic client proteins, revealing a novel therapeutic axis for metastatic disease. More details can be found in the Research Article by Jiayan Chen, Yaping Xu, Dongping Wei, and co-workers (DOI: 10.1002/advs.202509695).