CD207‐Positive Dendritic Cells Promote Emphysema Through CD8 + T Cell Pathway in Chronic Obstructive Pulmonary Disease
Source abstract
Abstract
ABSTRACT Emphysema remains a major challenge in the management of chronic obstructive pulmonary disease (COPD). This study identifies CD207‐positive dendritic cells (CD207 + DCs) as pivotal mediators of emphysema progression. In patients with COPD, the abundance of CD207 + DCs in small airways correlates with both emphysema severity and lung function decline (FEV 1 %pred). In a murine emphysema model, adoptive transfer of CD207 + DCs reversed the attenuation of emphysema, inflammation and CD8 + T‐cell expansion in CD207 ‐knockout mice. Mechanistically, cigarette smoke‐induced epithelial GM‐CSF drives the expansion of CD207 + DCs. Upon activation by damage‐associated molecular patterns (DAMPs), these DCs promote CD8 + T cell proliferation and activation via Birbeck granule‐mediated MHC‐I antigen cross‐presentation. Collectively, these findings demonstrate that CD207 + DCs orchestrate a pathogenic CD8 + T‐cell response in emphysema and represent a promising therapeutic target.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Chronic Obstructive Pulmonary Disease (COPD) Research · IL-33, ST2, and ILC Pathways · Cancer Immunotherapy and Biomarkers
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Respiratory & Critical Care Medicine the First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China
Department of Respiratory Medicine Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu China
Department of Thoracic Surgery Nanjing Chest Hospital Affiliated Nanjing Brain Hospital Nanjing Medical University Nanjing Jiangsu China
Emergency and Critical Care Center Department of Emergency Medicine Zhejiang Provincial People's Hospital (Affiliated People's Hospital Hangzhou Medical College) Hangzhou Zhejiang China
Airway Disease Section National Heart and Lung Institute Faculty of Medicine Imperial College London London UK
Funding
National Natural Science Foundation of China · Natural Science Foundation of Jiangsu Province
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