Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis (Adv. Sci. 48/2025)

Androgen Homeostasis In their Research Article (DOI: 10.1002/advs.202508240), Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan, and co-workers demonstrate that the liver plays a key role about androgen homeostasis in the development of DHEA-induced PCOS. KLF9 is required for the conversion of DHEA to DHT in hepatocytes. The image shows the liver origin T and DHT circulate to the ovary, leading to infertility. The upper island represents the liver and the under island represents the ovary.