Expanding the Chemical Space of Cyclic Polyphthalaldehyde via Post‐Functionalization
Source abstract
Abstract
ABSTRACT Cyclic polyphthalaldehydes (cPPAs) are hydrophobic cyclic polymers with stimuli‐responsive depolymerization property. The introduction of hydrophilic functionalities to cPPAs is challenging due to the intrinsic limitation of cationic polymerization. Herein, we developed a post‐functionalization approach to achieve water‐soluble cPPA derivatives with high molecular weight. The cPPA modified with cell‐penetrating oligoarginine underwent cellular uptake via endocytosis and acid‐triggered depolymerization in lysosome, which provided new potential for biological application.
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Research context
OpenAlex topics: Advanced Polymer Synthesis and Characterization · Dendrimers and Hyperbranched Polymers · Synthetic Organic Chemistry Methods
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry The State Key Laboratory of Synthetic Chemistry The University of Hong Kong Hong Kong SAR P. R. China
Laboratory for Synthetic Chemistry and Chemical Biology Limited Hong Kong Science Park Pak Shek Kok Hong Kong SAR P. R. China
Materials Innovation Institute for Life Sciences and Energy (MILES) HKU‐SIRI Shenzhen 518000 P. R. China
Shanghai‐Hong Kong Joint Laboratory in Chemical Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China
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