Nurr1 Orchestrates Claustrum Development and Functionality
Source abstract
Abstract
ABSTRACT Claustrum is the part of the forebrain known to be most widely interconnected tissue with almost all brain regions. It is believed to be involved in coordinating multiple cognitive behaviors including consciousness formation. However, little is known about the molecular mechanisms underlying its development and involvement in behavioral control. Here we show that Nurr1 (Nr4a2) is the key transcription factor orchestrating claustral morphogenesis, cell fate specification, connectivity and thus behaviors. Nurr1‐deficient claustral cells aberrantly migrate into insular cortex, shaping claustrum from a crescent‐like into a wing‐like structure. These cells ectopically turn on insular cortex genetic programs that were verified by single cell transcriptomics. Accordingly, functional connectivity of the claustrum is not properly formed and relevant behaviors are dysregulated in Nurr1‐deficient mice. Additionally, we show that Nurr1 regulates claustral neuron positioning and cell fate by suppressing Gαs‐PKA signaling.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nuclear Receptors and Signaling · Axon Guidance and Neuronal Signaling · Developmental Biology and Gene Regulation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Cell Biology and Neurobiology, Charité‐Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
Charité 3R – Replace | Reduce | Refine Charité – Universitätsmedizin Berlin Berlin Germany
Department of Experimental Neurology and Center for Stroke Research Berlin Charité – Universitätsmedizin Berlin Berlin Germany
Charité Core Facility Experimental MRIs, Charité‐Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
Department of Neurology, Charité‐Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
Berlin School of Mind and Brain Faculty of Philosophy Humboldt‐Universität Zu Berlin Berlin Germany
Animal Behavior Phenotyping Facility, Charité‐Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
Department of Genetics and Life Sciences Sirius University of Science and Technology Sirius Russia
Funding
Deutsche Forschungsgemeinschaft · Ministry of Science and Higher Education of the Russian Federation
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