Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency (Adv. Sci. 47/2025)

Neural Tube Defects with Folate Deficiency The cover image depicts a new mechanism of birth defect. Neural tube defects (NTDs) are among the most common congenital malformations. Folic acid deficiency in pregnant women increases the risk of developing NTDs, however the underlying etiology and mechanism remain elusive. In their Research Article (DOI: 10.1002/advs.202410603), Qiu Xie, Ting Zhang, and colleagues reveal that excessive DNA double-strand breaks associated three-dimensional genome reorganization contributes to NTDs with folate deficiency.