Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Wenxin Huang; Manli Wang; Yi Sun; Xiaoping Yue; Xun Li; Yanbing Lin; Geng Guo; Depeng Zhao; Qigang Fan; Xiaoling Ma; Zhihong Zhang; Shuaishuai Xing; Xiaoting Shen; Huidong Zhang

doi:10.1002/advs.202504871

journal article·2026-02Open access

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang

Advanced Science· Volume 13· Issue 7

Publisher page Open full text

Source abstract

Abstract

Abstract Unexplained miscarriage (UM) remains challenge due to unclear pathogenesis and biological mechanisms. BPB (Bisphenol B), an extensively used endocrine disrupting chemical, has been widely detected out in human. Migrasomes are newly identified cellular organelles with a large number of unknown functions. However, whether and how BPB exposure may suppress migrasome formation (MF) to induce miscarriage are completely unknown. In this study, it is found that higher urinary BPB levels are associated with the suppressed MF in villous tissues and unexplained miscarriage. It is further confirmed that BPB exposure suppresses MF in the mouse placenta and thus induces miscarriage. Supplement with Pkca or Tspan4, two essential proteins for migration/invasion (MI) and MF, can efficiently treat against BPB‐induced miscarriage. In biological mechanisms, BPB up‐regulates ER levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4‐mediated PKCA transcription and subsequently suppresses MI and MF. Collectively, this study not only identifies BPB as a novel risk factor for unexplained miscarriage, discovers novel pathogenesis and biological mechanisms in BPB‐induced miscarriage, but also provides potential targets for treatment against unexplained miscarriage.

Source: crossref · Quality: baseline

Research context

OpenAlex topics: Effects and risks of endocrine disrupting chemicals · Reproductive System and Pregnancy · Pluripotent Stem Cells Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Research Center for Environment and Female Reproductive Health The Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 China

Key Laboratory of Pharmaceutical Quality Control of Hebei Province College of Pharmaceutical Sciences Hebei University Baoding 071002 China

Department of General Surgery The First Hospital of Lanzhou University Lanzhou 730000 China

Department of Emergency Cerebrovascular Disease Center First Hospital of Shanxi Medical University Taiyuan 030001 China

Department of Reproductive Medicine Shenzhen Maternity and Child Healthcare Hospital Women and Children's Medical Center Southern Medical University Shenzhen Guangdong Province 518033 China

Department of Reproductive Medicine The First Hospital of Lanzhou University The First Clinical Medical School of Lanzhou University Lanzhou 730000 China

MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University Taiyuan 030001 China

NHC Key Laboratory of Male Reproduction and Genetics Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital) Guangzhou 510600 China

Funding

National Natural Science Foundation of China · Basic and Applied Basic Research Foundation of Guangdong Province · Science Fund for Distinguished Young Scholars of Hebei Province

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