Functional, Pharmacogenomic, and Immune Landscapes of Long Non‐Coding RNAs in Cancer
Source abstract
Abstract
Abstract Long non‐coding RNAs (lncRNAs) are emerging as key regulators in cancer, with significant potential as diagnostic, prognostic, and therapeutic targets. Here, this work systematically analyzes lncRNA associations with targeted therapies and immunotherapies across 33 cancer types using The Cancer Genome Atlas (TCGA) and real‐world datasets. This work identifies 53,173 lncRNA‐pathway associations, millions of lncRNA‐drug response associations (via CancerRxTissue and VAEN), and extensive correlations with immune checkpoints and infiltration. This work further identifies 69 lncRNAs associated with immunotherapy response and 2,611 differentially expressed lncRNAs between low and high objective response rate (ORR) groups. Additionally, two lncRNAs are correlated with immune‐related adverse events (irAEs), and 1,376 lncRNAs exhibited expression differences between cancers with low and high irAE risk. To facilitate further research, this work develops PILNC ( https://hanlaboratory.com/PILNC ), a comprehensive web portal enabling exploration of lncRNA associations with cancer pathways, drug responses, immune features, and immunotherapy outcomes.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Cancer-related molecular mechanisms research · Ferroptosis and cancer prognosis · Cancer Immunotherapy and Biomarkers
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biostatistics and Health Data Science Indiana University School of Medicine Indianapolis IN 46202 USA
Brown Center for Immunotherapy Indiana University School of Medicine Indianapolis IN 46202 USA
Center for Computational Biology and Bioinformatics Indiana University School of Medicine Indianapolis IN 46202 USA
Department of Psychological and Brain Sciences College of Arts and Sciences Indiana University Bloomington IN 47405 USA
Center for Epigenetics and Disease Prevention Institute of Biosciences and Technology Texas A&M University Houston TX 77030 USA
Department of Breast Medical Oncology The University of Texas MD Anderson Cancer Center 1515 Holcombe Blvd Houston TX 77030 USA
Department of Biochemistry and Molecular Biology The University of Texas Health Science Center Houston Houston TX 77030 USA
The Graduate School of Biomedical Sciences The University of Texas MD Anderson Cancer Center Houston TX 77030 USA
Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA
Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA
Funding
National Institutes of Health · Welch Foundation · National Science Foundation
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