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journal article·2026-01Open access

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit

Advanced Science· Volume 13· Issue 6
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Abstract

Abstract Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP), a significant global health burden. While glycosylation plays a key role in cellular signaling and inflammation, its role in IVD degeneration remains poorly understood. This study characterizes glycan alterations in human healthy and degenerated IVDs using glycomic (UPLC‐MS, MALDI‐IMS) and proteomic (LC‐MS) analyses, combined with functional studies. These results identify hypersialylation, especially α‐2,6‐linked sialic acid, as a prominent feature of degenerated IVDs. In vitro inhibition of sialylation (3Fax‐peracetyl Neu5Ac) in nucleus pulposus cells demonstrates reduced oxidative stress and inflammatory signaling, indicating a functional role for hypersialylation in IVD pathology. Targeting glycosylation pathways, notably sialylation, emerges as a promising therapeutic strategy for IVD degeneration.
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Research context

OpenAlex topics: Spine and Intervertebral Disc Pathology · Proteoglycans and glycosaminoglycans research · Glycosylation and Glycoproteins Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

CÚRAM Research Ireland Centre for Medical Devices Biomedical Sciences Building University of Galway Galway H91 W2TY Ireland

School of Medicine University of Galway Galway H91 TK33 Ireland

Department of Chemistry Maynooth University Maynooth W23 F2K8 Ireland

Department of Cell and Molecular Pharmacology Medical University of South Carolina Charleston South Carolina 29425 USA

Institute of Chemical Technologies and Analytics TU Wien Vienna 1060 Austria

National Institute for Bioprocessing Research and Training (NIBRT) Dublin A94 X099 Ireland

School of Medicine College of Health and Agricultural Science University College Dublin Dublin D04 C1P1 Ireland

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