journal article·2026-02Open access

Electron‐Mediator‐Free Microfluidic Photocatalytic Coenzyme Regeneration with 100% Conversion Efficiency within 126 S

Yao Chai, Liang Wan, Zirui Pang, Xu Li, Zixuan Jia, Heng Jiang, Chi Chung Tsoi, Huaping Jia, Jinni Shen, Zizhong Zhang, Jinlin Long, Fengjia Xie, Yanmei Chen, Xuming Zhang

Advanced Science· Volume 13· Issue 10

Abstract

Abstract Microfluidic systems enhance photocatalytic efficiency through superior mass/energy transfer and precise parameter control. Here, an electron‐mediator‐free microfluidic platform is designed for photocatalytic coenzyme NAD(P)H regeneration by integrating ultrathin BiOBr nanosheets. This architecture enables direct electron–proton coupling, achieving 100% NAD + conversion within 126 s with exceptional selectivity (72.30%) for bioactive 1,4‐NADH. Continuous operation over 32 h shows no activity decay, demonstrating unparalleled stability. This study establishes a benchmark for designing integrated photocatalytic systems and highlights their broad potential for applications in biocatalysis, synthetic biology, and renewable energy.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Metalloenzymes and iron-sulfur proteins · Advanced Photocatalysis Techniques · TiO2 Photocatalysis and Solar Cells

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Applied Physics The Hong Kong Polytechnic University Hong Kong Kowloon 999077 China

State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University Fuzhou 350116 China

Photonics Research Institute (PRI) The Hong Kong Polytechnic University Hong Kong Kowloon 999077 China

Funding

Hong Kong Polytechnic University

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