Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation (Adv. Sci. 41/2025)

CAR T Cell Immunotherapy Evaluation The complex physical and biochemical barriers of the tumor microenvironment are major triggers of immune exclusion. In their Research Article (DOI: 10.1002/advs.202508267), Michael Bachmann, Larysa Baraban, and co-workers demonstrate a 3D micrometastases model, developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy.