journal article·2026-01Open access

Impact of Intended Isocaloric Early versus Late Time‐Restricted Eating on Plasma Lipidome in Women with Overweight or Obesity: Secondary Analysis of the ChronoFast Trial

Kristof Szekely, Mathias J. Gerl, Beeke Peters, Julia Schwarz, Bettina Schuppelius, Markus Damm, Jorge R. Soliz‐Rueda, Ratika Sehgal, Michail Lazaratos, Christian Klose, Kai Simons, Andreas F. H. Pfeiffer, Annette Schürmann, Achim Kramer, Andreas Michalsen, Olga Pivovarova‐Ramich

Advanced Science· Volume 13· Issue 4

Abstract

Abstract Time‐restricted eating (TRE) is a promising strategy against metabolic disorders, but its effects on lipid metabolism remain controversial. The present research assesses and compares the impact of early (eTRE) versus late (lTRE) TRE on the plasma lipidomic profile. This is an exploratory outcome of the previously published randomized crossover trial, which examines 31 women with overweight or obesity who follow a two‐week eTRE and a two‐week lTRE in an intended isocaloric setting. Blood plasma and subcutaneous adipose tissue biopsies are analyzed using shotgun lipidomics and transcriptomics, respectively. Between interventions and within the lTRE, lipid species and classes, as well as enzyme activity indices, are not substantially changed. Within the eTRE, changes are observed for 103 lipid species, including a reduction of ceramide and phosphatidylcholine classes, and for the desaturation indices D5D, D6D, and D9D, as well as the elongation index ELOVL6. Combined analysis of plasma lipidome and adipose tissue reveals alterations in the glycerophospholipid pathway and in the expression of phospholipase enzymes PLB1, PLA2G6 , and PLAG4B , dependent on TRE timing. These results suggest that eating timing during TRE may be crucial for remodeling the plasma lipidome and adipose tissue transcriptome and highlight the need of future lipidomic research in TRE.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Dietary Effects on Health · Circadian rhythm and melatonin · Adipose Tissue and Metabolism

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Molecular Metabolism and Precision Nutrition German Institute of Human Nutrition Potsdam‐Rehbruecke 14558 Nuthetal Germany

Department of Endocrinology and Metabolism Charité – Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt‐Universität zu Berlin 10117 Berlin Germany

German Center for Diabetes Research (DZD) 85764 München‐Neuherberg Germany

Lipotype GmbH 01307 Dresden Germany

Institute of Agricultural and Nutritional Sciences Martin Luther University Halle‐Wittenberg 06120 Halle Germany

Nutrigenomics Research Group Biochemistry and Biotechnology Department Universitat Rovira i Virgili Tarragona 43007 Spain

Department of Experimental Diabetology German Institute of Human Nutrition Potsdam‐Rehbruecke 14558 Nuthetal Germany

Institute of Nutritional Science University of Potsdam 14558 Nuthetal Germany

Laboratory of Chronobiology Charité – Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt‐Universität zu Berlin 10117 Berlin Germany

Department of Internal and Integrative Medicine Immanuel Hospital Berlin 14109 Berlin Germany

Epidemiology and Health Economics Institute of Social Medicine Charité – Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin, and Humboldt‐Universität zu Berlin 10117 Berlin Germany

Funding

European Association for the Study of Diabetes

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