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journal article·2026-02Open access

Magnetoelectric Nanotherapy Achieves Complete Tumor Ablation and Prolonged Survival in Pancreatic Cancer Murine Models

John Michael Bryant, Max Shotbolt, Emmanuel Stimphil, Victoria Andre, Elric Zhang, Veronica Estrella, Kazim Husain, Joseph Weygand, Doug Marchion, Alex Sebastian Lopez, Dominique Abrahams, Shawnus Chen, Mostafa Abdel‐Mottaleb, Skye Conlan, Ibrahim Oraiqat, Vaseem Khatri, Jose Alejandro Guevara, Shari Pilon‐Thomas, Gage Redler, Kujtim Latifi, Natarajan Raghunand, Kosj Yamoah, Sarah Hoffe, James Costello, Jessica M. Frakes, Ping Liang, Robert A. Gatenby, Mokenge Malafa, Sakhrat Khizroev

Advanced Science· Volume 13· Issue 9
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Source abstract

Abstract

Abstract Magnetoelectric nanoparticles (MENPs), when activated by a magnetic field, are shown to provide a minimally invasive, drug‐free, theranostic approach to pancreatic ductal adenocarcinoma (PDAC) treatment. The magnetoelectric effect allows intravenously administered MENPs to be magnetically guided to PDAC tumors and remotely activated with a 7T‐MRI field to induce targeted, electrode‐free tumor ablation with real‐time imaging feedback. A single MENP treatment achieved a threefold median reduction in tumor volume and complete tumor responses in 33.3 % of mice at 300 and 600 µg doses ( N = 17) and significantly longer mean overall survival as compared to the control cohorts (54.1 vs 28.8 days, χ 2 = 40.14, p = 0.045), without evident toxicity in any imaged organ. In contrast, mice receiving subtherapeutic doses, non‐activated MENPs, or saline controls showed no significant response. MRI T 2 * relaxation time decreases closely correlated with tumor reduction (ρ = −0.73, p < 0.001), supporting MENPs as both a therapeutic and imaging biomarker. Mechanistically, MENPs preferentially target cancer cells via magnetic‐field‐driven electrostatic interactions specific to tumor cell membranes, in agreement with multiphysics numerical simulations. Flow cytometry confirmed that MENP activation primarily induces apoptosis, with minimal necrosis, and time‐course studies showed a progressive apoptotic response over 3‐hour post‐treatment. The findings establish MENPs as a versatile, image‐guided, theranostic platform with translational promise for minimally invasive oncology.
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Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Intraperitoneal and Appendiceal Malignancies · Pancreatic and Hepatic Oncology Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiation Oncology University of Miami Miller School of Medicine Miami FL 33136 USA

Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA

College of Engineering University of Miami Coral Gables FL 33146 USA

Cancer Physiology/Clinical Science Laboratory H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA

The Institute of Robotics and Intelligent Systems Swiss Federal Institute of Technology (ETH) Zurich Zurich 8092 Switzerland

Department of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA

Department of Radiation Oncology and Applied Sciences Geisel School of Medicine Dartmouth College Hanover NH 03755 USA

Tissue Core H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA

Department of Comparative Medicine University of South Florida Tampa FL 33612 USA

Department of Immuno‐Oncology H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA

Department of Diagnostic Imaging and Interventional Radiology H. Lee Moffitt Cancer Center and Research Institute Tampa FL 33612 USA

Cellular Nanomed Inc. Irvine CA 92617 USA

Department of Biochemistry and Molecular Biology Miller School of Medicine University of Miami Coral Gables FL 33136 USA

Funding

Defense Advanced Research Projects Agency · National Science Foundation · National Institutes of Health

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