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journal article·2025-10Open access

Nanomaterials Trigger Functional Anti‐Tumoral Responses in Primary Human Immune Cells (Adv. Sci. 39/2025)

Vincent Mittelheisser, Olivier Lefebvre, Mainak Banerjee, Shayamita Ghosh, Amandine Dupas, Marie‐Charlotte Diringer, Juliette Blumberger, Louis Bochler, Sébastien Harlepp, Annabel Larnicol, Angélique Pichot, Tristan Stemmelen, Anne Molitor, Chloé Moritz, Christine Carapito, Raphaël Carapito, Loïc J. Charbonnière, François Lux, Olivier Tillement, Jacky G. Goetz, Alexandre Detappe

Advanced Science· Volume 12· Issue 39
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Source abstract

Abstract

Immunotherapies In their Research Article (DOI: 10.1002/advs.202505729), Jacky G. Goetz, Alexandre Detappe, and co-workers investigate the molecular and functional responses of human NK and T cells to a panel of nanoparticles commonly used in biomedical applications, aiming to guide the rational design of future nanoimmunotherapies. Through proteogenomic mapping, they reveal that PLGA nanoparticles enhance the anti-tumor activity of NK cells under cytokine-deprived conditions, suggesting new strategies to reactivate immune responses in cancer patients.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Phagocytosis and Immune Regulation

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