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journal article·2025-12Open access

Laeverin is Cell‐Surface Target for Liquid‐Phase Metastasizing Cancer Cells

Haruki Kasama, Yuya Sakai, Kyosuke Kagami, Takashi Iizuka, Tatsuhito Kanda, Takuma Suzuki, Kayo Kayahashi, Masanori Ono, Tomoko Fujiwara, Shintaro Yagi, Noriyuki Inaki, Isao Matsumoto, Rena Yamazaki, Kaoru Abiko, Noriomi Matsumura, Akira Hattori, Takiko Daikoku, Hiroshi Fujiwara

Advanced Science· Volume 12· Issue 47
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Source abstract

Abstract

Abstract Laeverin (LVRN) is a cell‐surface immunoregulatory factor that is specifically expressed in embryo‐derived extravillous trophoblast, which invades maternal spiral arteries without immune rejection during human placentation. Here, it is found that various epithelial cancer cell lines upregulated LVRN expression in association with the expression of POU5F1 after spheroid formation under floating conditions. Immunohistochemically, LVRN expression is detected in the lesions of vascular, lymphatic, and peritoneal invasion of ovarian, cervical, endometrial, breast, and lung cancers. LVRN‐positive circulating tumor cells are also identified in the blood of uterine cervical and endometrial cancers, showing that LVRN expression is induced in cancer cells in the distant metastatic phase. Monomethylauristatin E‐conjugated anti‐LVRN antibody induced cell death in ovarian cancer‐derived cell lines in the liquid phase in vitro and inhibited their peritoneal dissemination in nude mice in vivo. These findings indicate that LVRN is a unique and promising cell‐surface target molecule for liquid‐phase metastasizing cancer cells.
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Research context

OpenAlex topics: MicroRNA in disease regulation · Caveolin-1 and cellular processes · Pregnancy and preeclampsia studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Obstetrics and Gynecology Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa 920‐8641 Japan

Department of Obstetrics and Gynecology Tokyo Medical University Nishi‐Shinjuku Shinjuku‐ku Tokyo 160‐0023 Japan

Department of Human Life Environments Kyoto Notre Dame University Kyoto 606‑0847 Japan

Department of Hepato‐Biliary‐Pancreatic Surgery and Transplantation Kanazawa University Hospital Kanazawa 920‑8641 Japan

Department of Gastrointestinal Surgery Kanazawa University Kanazawa 920‐8641 Japan

Department of Thoracic Surgery Kanazawa University Hospital Kanazawa 920‐8641 Japan

Department of Obstetrics and Gynecology Kindai University Faculty of Medicine Osaka 589‑8511 Japan

Department of System Chemotherapy and Molecular Sciences Kyoto University Graduate School of Pharmaceutical Sciences Kyoto 606‐8501 Japan

Division of Animal Disease Model Research Center for Experimental Modeling of Human Disease Kanazawa University Kanazawa Ishikawa 920‐8640 Japan

Ochi Yume Clinic Nagoya Nagoya 460‐0002 Japan

School of Veterinary Medicine Azabu University Sagamihara 252‐5201 Japan

Funding

Japan Agency for Medical Research and Development

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