journal article·2025-08Open access

Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development (Adv. Sci. 30/2025)

Xiaoyu Zhang, Zizhang Li, Jingyu Chen, Wenjing Yang, Xingxing He, Peng Wu, Feng Chen, Ziwei Zhou, Chenze Ren, Yuyan Shan, Xiewen Wen, Vassily A. Lyubetsky, Leonid Yu. Rusin, Xiaoshu Chen, Jian‐Rong Yang

Advanced Science· Volume 12· Issue 30

Abstract

Stereotyped Subclones in Development On this cover, a tree represents the cell lineage tree, with outward-reaching branches ending in colorful tips symbolizing cell types. Repeated subtrees within the structure highlight the stability of cell type composition in multicellular organisms during robust development. This artwork reflects the findings of Xiaoyu Zhang, Jian-Rong Yang, and co-workers described in article number 2406208, revealing how stereotyped subclones and coordinated lineage structures ensure developmental stability. The cover art was created by Coloring Zehao.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Single-cell and spatial transcriptomics · Cancer Genomics and Diagnostics

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