The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots (Adv. Sci. 31/2025)

Anthrobots This cover captures an “Anthrobot,” a self-constructing multicellular spheroid grown from a single adult human airway epithelial cell. Without genetic engineering or inorganic scaffolds, Anthrobots undergo distinct developmental modes, display embryonic gene-patterning programs and a phylogenetically ancient transcriptome, self-repair, and achieve epigenetic rejuvenation–revealing a novel living architecture with its own life cycle and dynamic behaviors. More details can be found in article number 2409330 by Gizem Gumuskaya, Michael Levin, and co-workers.