Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model (Adv. Sci. 31/2025)

Reconstruct Neural Networks In article number 2500400, Vittoria Raffa, Fabian Raudzus, and co-workers present a novel approach to reconstruct neural networks in an organotypic Parkinson's model. Using a technique called nano-pulling, magnetic forces are applied to guide axonal growth of nanoparticle-loaded human cortical neural and iPSC-derived dopaminergic progenitors.