Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition (Adv. Sci. 27/2025)
Source abstract
Abstract
Dual-Locking the SARS-CoV-2 Spike Trime An amphipathic small molecule acts as a “bolt,” stabilizing SARS-CoV-2 Spike in its closed state via a novel dual-locking mechanism at conserved RBD-RBD/NTD-RBD interfaces, hinting at broad-spectrum anti-coronavirus potential. More details can be found in article number 2417534 by Ke Xu, Yang Du, Honglin Li, and co-workers.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Lipid Membrane Structure and Behavior · Luminescence and Fluorescent Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References
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