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journal article·2025-08Open access

Fast pH‐Driven Solubilization Method of Realgar (As 4 S 4 ) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes (Adv. Sci. 29/2025)

Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino

Advanced Science· Volume 12· Issue 29
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Source abstract

Abstract

Acute Promyelocytic Leukemia The mineral realgar (As4S4), an orange-brown painting pigment widely used in ancient Egypt, has recently become a valuable drug against acute promyelocytic leukemia (APL) in China. It mainly targets nuclear bodies (NB), altered in APL. The study of Iart Luca Shytaj, Andrea Savarino, and co-workers casts new light on the selective activity of realgar against APL and discloses potential novel medicinal uses of it. More details can be found in article number 2502740.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Arsenic contamination and mitigation

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