Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding (Adv. Sci. 29/2025)

Wenqian Chen; Yuwei Zhou; Wenxiu Yuan; Yanjing Ou; Hanyu Lin; Kaixun He; Xueshen Qian; Huachen Chen; Chengchaozi Wang; Jie Lu; Weiping Chen; Dexiong Li; Jiang Chen

doi:10.1002/advs.71023

journal article·2025-08Open access

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding (Adv. Sci. 29/2025)

Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen

Advanced Science· Volume 12· Issue 29

Publisher page Open full text

Source abstract

Abstract

Joint Osteoarthritis Eosinophils are crucial in the progression of temporomandibular joint osteoarthritis (TMJOA). In article number 2416030, Jiang Chen and co-workers show OVA/IL-5-induced eosinophils promote synovial Lumican, which binds chondrocyte Anxa1 to inhibit TGFβ2/Smad2/3 signaling. This reduces cartilage matrix degradation, synovitis, and bone erosion, delaying TMJOA. Eosinophil-stimulated Lumican emerges as a promising therapeutic target for TMJOA treatment.

Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Osteoarthritis Treatment and Mechanisms

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References

Reference metadata was not supplied for this record.