High‐Throughput Tiling of Essential mRNAs Increases Potency of Antisense Antibiotics (Adv. Sci. 28/2025)

PNA-Based Antisense Antibiotics Silencing Bacterial Genes The frontispiece illustrates the molecular action of the high-throughput approach to identify potent antisense antibiotics targeting essential bacterial mRNAs. PNA-based molecules, depicted in blue, yellow, and red stick-and-ball models, selectively hybridize with their RNA targets, silencing critical genes and leading to bacterial death. More details can be found in article number 2504284 by Jörg Vogel, Hans M. Maric, and co-workers. Image created by Juan Gärtner.