Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease (Adv. Sci. 26/2025)

Hyoyong Kim; Junseok Lee; Audrey Qian; You‐Ren Ji; Ryan Zhang; Qixin Hu; Christopher Kazu Williams; Han‐Yu Chuang; Matthew D. Smalley; Yaya Xu; Liang Gao; Mary C. Mayo; Ting Zhang; Edwin M. Posadas; Zaldy S. Tan; Harry V. Vinters; Keith Vossel; Shino Magaki; Yazhen Zhu; Hsian‐Rong Tseng

doi:10.1002/advs.202570205

journal article·2025-07Open access

Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease (Adv. Sci. 26/2025)

Hyoyong Kim, Junseok Lee, Audrey Qian, You‐Ren Ji, Ryan Zhang, Qixin Hu, Christopher Kazu Williams, Han‐Yu Chuang, Matthew D. Smalley, Yaya Xu, Liang Gao, Mary C. Mayo, Ting Zhang, Edwin M. Posadas, Zaldy S. Tan, Harry V. Vinters, Keith Vossel, Shino Magaki, Yazhen Zhu, Hsian‐Rong Tseng

Advanced Science· Volume 12· Issue 26

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Source abstract

Abstract

Alzheimer's Disease In article number 2415289, Junseok Lee, Yazhen Zhu, Hsian-Rong Tseng, and co-workers present the NEV β-secretase activity assay, a groundbreaking method for noninvasive evaluation of β-secretase activity in Alzheimer's disease (AD) patients, enabling the generation of individualized β-secretase activity profiles. The cover illustrates a brain AD, with neuron-derived NEV selectively enriched via click chemistry, followed by quantifying activity of NEV-derived β-secretase using FRET probes for AD diagnosis.

Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Supramolecular Self-Assembly in Materials · Lipid Membrane Structure and Behavior · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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