Self‐Propelled In Situ Polymerized Nanoparticles Activating the STING Pathway for Enhanced Bladder Cancer Immunotherapy (Adv. Sci. 25/2025)

Enhanced Bladder Cancer Immunotherapy A self-propelled nanomedicine delivery system forms Mn-cGAMP@PDA-urease (DMCU) nanoparticles in the bladder via in situ polymerization of dopamine hydrochloride, Mn2+, cGAMP, and urease. The urease-driven propulsion enhances retention and drug delivery. These nanoparticles activate the STING pathway, stimulating dendritic cells and T cells to boost anti-bladder cancer immunity. More details can be found in article number 2502750 by Rui Liang, Shaohua Zhang, Song Wu, and co-workers.